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Hematopoietic Stem Cells: Keystone of Tissue Development and Regenerative Medicine (Advances in Experimental Medicine and Biology #1442)
A new book, titled Hematopoietic Stem Cells: Keystone of Tissue Development and Regenerative Medicine, has been recently published by Springer. The book is edited by Dr. Meng Zhao and Dr. Pengxu Qian.The book provides a comprehensive understanding of HSCs from embryonic development through adult maintenance to aging. It covers the latest research in epigenetics, metabolism, microenvironment and advanced technologies that are relevant to HSC biology and clinical applications. The book also offers a good reference for experimental and clinical hematologists, scientists in ste...
Comment: Forever young: Sphk2 in HSCs, when less is more
Victoria da Silva-Diz, Daniel HerranzIn this issue of Blood, Li et al1 use different mouse models to comprehensively dissect the role of sphingosine kinases (Sphks) in the regulation of hematopoietic stem cell (HSC) function, uncovering that specific loss of Sphk2 expands and functionally rejuvenates HSCs.HSCs sustain the lifelong production of most adult blood and immune cell lineages. At the apex of the hematopoietic system, HSCs are characterized by their capacity for long-term self-renewal and their ability to differentiate into mature cells.2 The decline in their ...
Comment: RIG-Ing out BMSCs for hematopoietic recovery after transplantation
Simón Méndez-FerrerIn this issue of Blood, Lou et al1 show that all-trans retinoic acid (ATRA) and different inflammatory signals increase the expression of retinoic acid (RA)-inducible gene I (RIG-I) in bone marrow (BM) mesenchymal stem cells (BMSCs), reducing their reactive oxygen species (ROS) buffering capacity and their hematopoietic supportive function after transplantation.The impact of cancer treatment on the BM niche and its consequences for hematopoiesis is an emerging research field with therapeutic potential. In their article, Lou et al show that ATRA and...
Comment: Revisiting PD-1 to target leukaemic stem cells
Chong Yang & Toshio SudaThe programmed cell death protein 1 (PD-1) -programmed death-ligand 1 (PD-L1) axis is emerging as an immune checkpoint that regulates anti-tumour immune responses against solid tumours and haematological malignancies[1] , but its function in T cell acute lymphoblastic leukaemia (T-ALL) leukaemogenesis remains unknown. Accumulative studies have demonstrated that tumours are composed of hierarchically heterogeneous populations of cells, with cancer stem cells representing a distinct subset that dwells at the apex of the hierarchy wit...